Muddy River Marathon

Experience the thrill of the 5th Annual Muddy River Marathon on May 2, 2026, in picturesque Cape Girardeau. This scenic marathon takes you on a journey past Cape Girardeau's notable landmarks like the Bill Emerson Bridge and Common Pleas Courthouse, offering a flat course suitable for all levels of runners. Whether you're a seasoned athlete or a first-time participant, there are various race distances to choose from. As you complete the race at the Missouri Wall of Fame Mural, not only will you savor your achievement but also contribute to the community's well-being. With proceeds supporting local non-profits, the Muddy River Marathon has donated over $70,000 to date. Join us for a day of fitness, fun, and philanthropy, uniting for a worthy cause in Southeast Missouri.